模型信息
中文名称:SARS-CoV-2 C57BL/6 Ad5- hACE2转基因小鼠鼻内途径感染模型
英文名称:SARS-CoV-2 C57BL/6 Ad5- hACE2 transgenic mice intranasally infected model
类型:SARS-CoV-2感染动物模型
分级:NA
用途:用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。
研制单位:北京协和医院@@http://www.pumch.cn/learning.html
保存单位:北京协和医院@@http://www.pumch.cn/learning.html
研究背景
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制备方法
Mice were treated with adriamycin(ADR),a well- established chemical that induced stress and injury in the myocardium. Mice were anesthetized with isoflurane and intranasally administered with 2.5 × 10^8 Ad5- hACE2 in 50 μL DMEM. mice were intranasally infected with SARS- CoV- 2 stock virus at a dosage of 10^5 TCID50 .
评价验证
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生物安全性
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讨论与结论
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了解中析
实验室仪器
合作客户
